Decomposition of D-Ribose Producing Formaldehyde
作者单位：State Key Laboratory of Brain and Cognitive ScienceInstitute of BiophysicsUniversity of Chinese Academy of Sciences Southwest Medical University Alzheimer's Disease CenterBeijing Institute for Brain DisordersCapital Medical University
会议名称：《中国生物化学与分子生物学会第十二届全国会员代表大会暨2018年全国学术会议》
会议日期：2018年
学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100403[医学-营养与食品卫生学] 10[医学]
关 键 词：D-ribose formaldehyde anti-aging nutrient glyceraldehyde
摘 要：Although D-ribose is reputedly a key anti-aging nutrient and provided as a supplement to elderly people to improve their health,no laboratories have reported that D-ribose is involved in the production of formaldehyde(FA) under the physiological pH *** is toxic and has been implicated in the pathologies of various diseases,such as neurodegenerative diseases and ***,to improve the safety of D-ribose supplementation,we show that formaldehyde can be produced from decomposition of D-ribose in solution.D-ribose first decomposed into glyceraldehyde(GA),followed by production of formaldehyde under neutral and alkaline *** experiments showed that formaldehyde was produced in the presence of D-ribose in a lysine *** formaldehyde is produced in the presence of norleucine(containing an α-amino group) compared with 6-aminocaproic acid(containing an ε-amino group),which indicates that the α-amino group of amino acids plays an active role in the decomposition of *** with glycine further confirmed this *** work suggests the concentration of formaldehyde produced during administration of D-ribose should be carefully monitored in the elderly who are receiving D-ribose as an anti-aging supplement.