Copper(Ⅰ)-Catalyzed Cycloaddition between Azomethine Imines and vinylidene(bis)phosphonate under Additive-Free Conditions
作者单位:Key Laboratory of Tropical Medicinal Plant Chemistry of the Ministry of Education College of Chemistry & Chemical EngineeringHainan Normal University
会议名称:《中国化学会第十四届全国有机合成化学学术研讨会》
会议日期:2017年
学科分类:081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学]
关 键 词:azomethine imines vinylidene(bis)phosphonate cycloaddition
摘 要:Many bicyclic polyhydropyrazolo[1,2-a]pyrazolone derivatives have important medicinal *** shown in Figure 1,compounds A and B are antibacterial agents that are analogues of penicillin and *** addition,nitrogen-containing bisphosphonate(N-BPs)drugs are used to treat a variety of bone resorption diseases,such as osteoporosis,Paget’s disease,and hypercalcemia due to *** are thought to act by inhibiting the enzyme farnesyl diphosphate synthase,resulting in inhibition of protein prenylation in *** is worth mentioning that most of the highly potent third-peneration BP drugs contain the nitrogen heterocyclic component in their molecular structures,as in risedronate and zoledronate,and for the treatment of bone diseases associated with excessive resorption,the cyclic nitrogen bisphosphonate(N-BPs)are up to 10,000-fold more active than the first-generation non-nitrogen containing BP,for example,***,the purposeful synthesis of new members of cyclic nitrogen containing N-BP family is of current interest for further development of more potent drugs.