Obesity may provide a pro ILC3s development inflammatory environment in asthmatic
作者单位：THE FIRST PEOPLR’S HOSPITAL OF CHANGZHOU
会议名称：《第十三届全国免疫学学术大会》
会议日期：2018年
学科分类：1002[医学-临床医学] 100202[医学-儿科学] 10[医学]
关 键 词：Obesity Asthma Group 3 innate lymphoid cells IL-17A
摘 要：The prevalence of obesity in children has dramatically increased in the last few decades, and obesity has also emerged as an important risk factor for asthma.Innate mechanisms have been shown to be involved in both diseases, particularly through the recently described innate lymphoid cells(ILCs), in which ILC3s have been linked to obesity both in human and in murine models.The aim of this study was to explore whether being overweight in asthmatic children was associated with elevated circulating ILC3 or elevated messenger RNA(mRNA)-levels of RORC, IL-17A and IL-22.Our results showed significantly elevated ILC3 frequencies in overweight asthmatic children compared with non-overweight controls based on the detection of Lin+CD127IL-23R cells by flow cytometry.Moreover, elevated ILC3 frequencies positively correlated with the mRNA expression of RORC which has been identified as a transcription factor of ILC3s.The relative mRNA expression level of IL-17A was also upregulated in overweight compared to non-overweight children, as was the relative mRNA level of IL-22.However, there were no correlations between ILC3s frequencies or the expression of, RORC, IL-17A and IL-22 and asthma severity.These results suggested that childhood obesity is an independent factor that is associated with an elevated frequency of circulating ILC3s and higher expression of RORC, IL-22 and IL-17A.