Bacillus licheniformis normalize the ileum microbiota of chickens infected with necrotic enteritis
作者单位：Animal Microecology InstituteCollege of Veterinary MedicineSichuan Agricultural University Key Laboratory of Animal Disease and Human Health of Sichuan ProvinceSichuan Agricultural University
会议名称：《中国畜牧兽医学会动物微生态学分会第五届第十三次全国学术研讨会》
会议日期：2018年
学科分类：090603[农学-临床兽医学] 09[农学] 0906[农学-兽医学]
基 金：International Cooperative Project of Science and Technology Bureau of Sichuan Province (2013HH0055,2014FZ0076) Agricultural science and technology research and development project of Chengdu science and Technology Bureau(2015-NY02-00295-NC)
关 键 词：Bacillus licheniformis Broiler chickens Necrotic enteritis Illumina MiSeq sequencing Ileum Microbiota
摘 要：Necrotic enteritis(NE) is a severe intestinal disease,which can change gut microbiota and result in a high cost for the poultry industry ***,little is known regarding how the gut microbiota of NE chicken ileum are changed by Bacillus *** study was conducted to investigate how ileum microbiota structure was changed by *** in broiler chickens challenged with Clostridium perfringens-induced NE through Illumina MiSeq *** broilers were randomly separated into four groups:the negative control group(NC),the positive control group(PC),the fishmeal and coccidia group(FC),and the PC group supplied with feed containing ***(BL).Compared to the PC and FC,alpha diversity,beta diversity,and the bacterial taxa of the ileum microbiota were more similar in BL and *** genera,which were related to the NE control,became insignificant in BL with NC,such as Lactobacillus,Lactococcus,Bacteroides,Ruminococcus and *** PICRUSt analysis revealed that a tumour suppressor gene,p53,which was negatively correlated with Helicobacter,was enriched in the BL *** findings showed that the ileum microbiota disorder caused by NE in chickens was normalized by dietary *** supplementation.