D-ribose induces the synthesis of triglyceride in liver through increase of DGAT
作者单位：Southwest Medical University Institute of BiophysicsUniversity of Chinese Academy of Sciences Affiliated Hospital of Southwest Medical University
会议名称：《中国生物化学与分子生物学会第十二届全国会员代表大会暨2018年全国学术会议》
会议日期：2018年
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
关 键 词：D-ribose triglyceride DGAT lipid liver T2DM
摘 要：Glucotoxicity and lipotoxicity are the key characteristics of type 2 diabetes mellitus(T2 DM) in early *** reports demonstrated that patients of T2 DM suffered from abnormal high levels not only of D-glucose but also of ***(TG) is the main lipid molecule involved in hyperlipidaemia,atherosclerosis,coronary heart disease and T2 ***,we aimed to investigate the relationship of D-ribose and lipid metabolism in liver-target *** O-acyltransferase(DGAT) is the key enzyme in esterification reaction,playing an important role in the last process of triglyceride synthesis in *** this study,SD rats were intraperitoneally injected with D-ribose(4 g/kg),D-glucose(4.8 g/kg) or normal saline once daily for two *** results showed that rats of D-ribose group got a significant increase in liver TG and DGAT levels compared with the normal saline *** staining of liver revealed that the structure of hepatic lobules was disordered and even disappeared,and hepatocytes were extensively edematous accompanied with steatosis in D-ribose treated ***,there were no significant biochemical and pathologic changes in D-glucose injected ***,seventy volunteers were recruited to participate a double-blind trial including laboratorial assays and color dopplar ultrasound *** results showed that urine D-ribose and serum TG levels of participants with fatty liver were significantly higher than those of non-fatty liver.D-ribose levels was significantly positive correlated with serum *** suggest that D-ribose might induce the over-production of TG in liver through increase of *** work could help with the exploring of abnormal lipids metabolism and may propose a novel research idea for the lipid dysmetabolism in T2 DM.