Captive breeding alters the gut microbiome of giant panda
作者单位：Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan ProvinceSichuan Agricultural University Department of Laboratory MedicineChengdu Medical College China Conservation and Research Center for the Giant Panda Department of Animal ScienceDivision of AgricultureUniversity of Arkansas Institute of Quality and Standard for Agro-productsZhejiang Academy of Agricultural Sciences
会议名称：《中国畜牧兽医学会动物微生态学分会第五届第十三次全国学术研讨会》
会议日期：2018年
学科分类：0907[农学-林学] 090705[农学-野生动植物保护与利用] 09[农学]
关 键 词：captivity gut microbiome giant pandas antibiotic resistance genes metagenomics diversity metal tolerance genes virulence factors
摘 要：Captive breeding has been used as an effective approach to protect endangered animals but its effect on the gut microbiome and the conservation status of these species is largely *** giant panda is a symbol of *** integrated efforts including captive breeding,this species has been recently upgraded from endangered to vulnerable.Since a large proportion(21.8%) of the population is captive,it is critical to understand how captivity changes the gut microbiome of these pandas and how such alterations to the microbiome might affect their future fitness and potential impact on the ecosystem after release into the *** we use 16 S rRNA marker gene sequencing and shotgun metagenomics sequencing to demonstrate that the fecal microbiomes differ substantially in wild and captive giant *** microbiome diversity was significantly lower in captive pandas,as was the diversity of functional ***,captive pandas had reduced functional potential for cellulose degradation but enriched metabolic pathways for starch metabolism,indicating a reduced fitness when releasing into the wild since their major diet in the wild will be ***,antibiotic resistance genes and virulence factors,as well as heavy metal tolerance genes were enriched in the microbiomes of captive pandas,which raises a huge concern of spreading these genes to other wild animals and the ecosystem after releasing them to the wild *** results clearly show that captivity has altered the giant panda microbiome,which could have unintended negative consequences on their fitness and the ecosystem during the re-introduction of giant pandas into the wild.