Analysis of Cell Circuit Model and Simulation of Transmembrane Potential
作者单位：School of Information Engineering Inner Mongolia University of Science and Technology
会议名称：《第30届中国控制与决策会议》
会议日期：2018年
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：supported by National Nature Science Foundation under Grant 61301073 Creation Foundation of Inner Mongolia University of Science and Technology under Grant 2016QDL-B23
关 键 词：Cell Circuit Model Transmembrane Potential Irreversible Electroporation Simulation
摘 要：A more realistic multi-channel cellular model, which is based on the classic spherical single-cell dielectric model and takes into account the influence of different parts of the cell on the transmembrane potential, is proposed. Methods for calculating transmembrane potential of cytomembrane and nuclear envelope and modeling the transfer function of each part of the cell membrane voltage are introduced. The experimental results show that different cells have different membrane voltage response to the same parameters of electrical pulse, which also explains that the stimulating effect for electrical pulses to the cell is selective. The optimal pulse parameters which are suitable for tumor treatment can be found and that could achieve a better therapeutic effect on tumor tissues and minimize the side effects on normal cells. The validity of the multi-channel cellular circuit model has been verified.