Design and Synthesis of Potential Antimicrobial Azolylalcohol Carbazoles
作者单位：School of Chemistry and Chemical Engineering Southwest University
会议名称：《中国化学会第十四届全国有机合成化学学术研讨会》
会议日期：2017年
学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学]
基 金：supported by the National Natural Science Foundation of China(no.21672173,21372186) Program for International Young Scientists from State Bureau of Foreign Experts Affairs,China(WQ2017XNDX047)
关 键 词：carbazole azolylalcohol ring opening reaction DNA interaction
摘 要：A series of novel carbazole-derived azolyl ethanols as potentially antimicrobial agents were designed and synthesized from commercially available carbazole,epichlorohydrin and *** antimicrobial assay revealed that3,6-dichlorocarbazole triazolyl ethanol 3f exhibited comparable or superior inhibitory activities against some tested strains to reference drug and the active molecule 3f also showed lower activity in triggering the development of resistance in bacteria than *** with DNA suggested that it could form 3f–DNA complex by intercalating into DNA,which might be a possible mechanism for its antimicrobial action.