Chemically-Defined Natural N-Glycan Scaffold Efficiently Delivers Toxins to B-Lymphoma Cells

作     者：彭文杰 James C Paulson 

作者单位：Departments of Molecular Medicine and Department of Immunology ＆ Microbiology The Scripps Research Institute 

会议名称：《第二届糖合成化学青年学术研讨会》

会议日期：2017年

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070305[理学-高分子化学与物理] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 

基　　金：supported by grants R01AI050143 P01HL107151 R01AI099141 from the NIH(to JCP) 

摘      要：正CD22 is a sialic acid-binding immunoglobulin-like lectin（Siglec）that is highly expressed on B-cell lymphomas,and is a validated target for antibody and nanoparticle based therapeutics;However,such cell targeted therapeutics are limited by their complexity,heterogeneity and difficulties in *** describe here a chemically-defined natural N-linked glycan scaffold for presenting multiple high affinity