New Application of 3,4-Dihalo-2（5H）-furanone Derivatives in Catalyst-free Three-component Reaction for the Synthesis of Arylsulfonyl Dihalomethanes
作者单位：School of Chemistry and EnvironmentSouth China Normal University
会议名称：《中国化学会第十三届全国有机合成化学学术研讨会》
会议日期：2016年
学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学]
基 金：广东省自然科学基金(No.2014A030313429) 广州市科技计划科学研究专项(No.201607010251)资助项目
关 键 词：3,4-dihalo-2(5H)-furanone three-component reaction metal-free
摘 要：Molecules possessing 2（5 H）-furanone moiety are receiving increasing attention due to the significant biological activities,such as antifungal,antibacterial,anti-inflammatory,and anticancer.1 At the same time,many 3,4-dihalo-2（5 H）-furanone compounds are important synthons in organic synthesis and material preparation.2 Recently,we found a new catalyst-free three-component reaction for the preparation of important compounds arylsulfonyl dibromomethanes without the needs of anaerobic atmosphere from sodium arylsulfinate 1,3,4-dibromo-5-hydroxy-2（5 H）-furanone 3（X = Br,R = OH） and solvent DMSO（2）.3 Herein,we further found that other 3,4-dihalo-2（5 H）-furanone derivatives 3 also could take part in this mild metal-free three-component reaction to synthesize arylsulfonyl dihalomethanes ***,the yields were affected by 5-position functional group slightly while halogen kinds seriously.