Structural Modeling of Human Desmocollin-2 Using I-TASSER Methods
作者单位：Unit of BiochemistryFaculty of MedicineAIMST UniversityBedongKedahMalaysia Unit of PsychiatryFaculty of MedicineAIMST UniversityBedongKedahMalaysia School of Biosciences and TechnologyVIT UniversityVelloreTamilnaduIndia
会议名称：《2012 International Conference on Biological and Life Sciences》
会议日期：1000年
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
关 键 词：Desmocollin I-TASSER C-score RMSD.
摘 要：Desmosomes are well defined contact structures involved in cell-cell adhesion of *** proteins of cadherin class are desmoglein-2 and desmocollin-2 which are found to be critical in the disease mechanism of arrhythmogenic right ventricular cardiomyopathy （ARVC） in *** desmocolin-2 mutations area major contributory *** the advance of computational methods,there is a need for research on structural biology of desmocollin-2 which could lead to annotation of protein function and drug *** of desmocollin-2 domain was carried out by PFAM and secondary structure prediction using GOR *** 3D structural model was generated using I-TASSER based on threading *** assessment of structural models wasdone with C-score,TM score and *** 1 was found to be the best and was validated using PROCHECK.