Growth Inhibition and Induction of apoptosis in sarcoma 180 cells by juglone in vivo
会议名称：《2008 International Seminar on Future BioMedical Information Engineering(FBIE 2008)》
会议日期：2008年
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：supported by Supported by National Natural Science Foundation of China(No.30600816) the Research Fund for the Doctoral Program of Higher Education of China (No.20060240001)
关 键 词：Juglone sarcoma180 cells apoptosis subdiploid peak in vivo
摘 要：To study the effect of growth inhibition and induction of apoptosis in sarcoma 180 cells by juglone in vivo.S180 tumor-bearing mice were set up to investigate the effects of juglone on tumor growth inhibition and *** HE staining,the pathomorphologic changes of tumor cells were observed by optical *** ultrastructural changes of tumor cells were observed by transmission electron *** cytometry was used to observe the apoptosis rate in S180 *** experimental results showed that the tumor inhibition rate at the dosage of 2,4 and 8μmol/kg of juglone was 29.04%,37.33%,52.66% *** tumor weight of all dose groups of juglone were lower significantly than that in blank control group （P0.01）.The typical morphological changes of apoptosis were observed,such as chromatin condensation,margination against nuclear envelope and formation of apoptotic bodies by transmission electron *** subdiploid peak was found and the apoptosis rate of juglone at the dosage of 2,4 and 8 μmol/kg was 5.58±0.63%,6.66±0.85%,10.27±1.05% *** can inhibit the growth and induce apoptosis of sarcoma 180 cells in vivo.