Metallothionein-Null mouse exhibits reduced tolerance to ultraviolet B injury in vivo
会议名称：《International Forum 2003 Academic Conference of Dermatology of the Integration of TCM with Western Medicine》
会议日期：2003年
学科分类：1001[医学-基础医学(可授医学、理学学位)] 100104[医学-病理学与病理生理学] 10[医学]
关 键 词：gene, knock out, metallothionein, mouse, sunburn cell,UVB
摘 要：Background: Events that induce expression of metallothionein （MT）gene, such as injection of cadmium chloride, cold stress and topical applica-tion of 1.25 dihydroxyvitamin D, can deplete the number of UVB-inducedsunburn cells in mouse skin in vivo. MT-null mouse skin explants exhibitedreduced tolerance to UVB injury in vitro. However, the in vivo response ofMT-null mouse to UVB injury has not been investigated.