A Novel Subset of B7-H3+CD14+HLA-DR-/low Myeloid-derived suppressor cells are Associated with Progression of Human NSCLC
作者单位：Clinical Immunology LaboratoryThe First Affiliated Hospital of Soochow University Institute of Medical BiotechnologyThe First Affiliated Hospital of Soochow University Department of Thoracic Surgery The First Affiliated Hospital of Soochow University Clinical Immunology Laboratory The First Affiliated Hospital of Soochow University Institute of Medical Biotechnology The First Affiliated Hospital of Soochow University
会议名称：《第十四届全国肿瘤生物治疗大会》
会议日期：2015年
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
摘 要：Myeloid-derived suppressor cells(MDSC) potently inhibit antitumor immune responses, and thereby promoting tumor progression and metastasis. However, the nature of human tumor-infiltrating MDSC remains poorly characterized. Here, we found that B7-H3 was exclusively expressed on a subset of intratumoral CD14+HLA-DR-/low MDSC but not on those from adjacent normal lung tissues of the cancer patients. Cytokine analysis revealed that B7-H3+CD14+HLA-DR-/low MDSC(B7-H3+MDSC) produced higher levels of IL-10 and TNF-α but lower levels of the IL-1β and IL-6 when compared with B7-H3-CD14+HLA-DR-/low MDSC(B7-H3-MDSC). In a murine lung cancer model, B7-H3+MDSC were found only in the tumor microenvironment and their frequencies increased during tumor progression. Clinical data analysis indicated that higher frequencies of B7-H3+MDSC were associated with reduced recurrence-free survival in patients with NSCLC. Taken together, we identify a novel subset of MDSC within the tumor microenvironment that leads to tumor progression.