Decidual macrophage M1 polarization contributes to adverse pregnancy induced by Toxoplasma gondii infection
作者单位：Binzhou Medical University
会议名称：《第十二届全国免疫学学术大会》
会议日期：2017年
学科分类：1002[医学-临床医学] 100211[医学-妇产科学] 10[医学]
关 键 词：Toxoplasma gondii decidual macrophages polarization adverse pregnancy outcomes
摘 要：Recent evidence indicates that macrophages at the maternal-fetal interface adapt to a phenotype characterized by alternative activation(M2 polarization) and exhibit immunosuppressive functions that favor the maintenance of *** bias of M2 decidual macrophages toward M1 has been clinically linked to pregnancy-related complications,such as preeclampsia,and preterm *** aim of this study was to investigate the effect of Toxoplasma gondii infection on the bias of decidual macrophage polarization and its contribution to adverse pregnancy outcomes.A mouse model with adverse pregnancy outcome was established by infection with *** PRU *** expression levels of CD80,CD86,CD206,MHC-Ⅱ,iNOS,arginase-1,IL-10,TNF-α,and IL-12 in decidual macrophages of infection and control mice were *** results showed that the expression of CD206,MHC-Ⅱ,and arginase-1 considered as M2 markers was decreased in decidual macrophages after *** infection,whereas the expression of CD80,CD86,iNOS,and cytokines TNF-α and IL-12 considered as M1 markers was *** results indicated that *** infection was responsible for the bias of M2 decidual macrophages toward M1,which changes the immunosuppressive microenvironment at the maternal-fetal interface and contributes to adverse pregnancy outcomes.