Hydrogen Sulfide Enhances Hippocampal Autophagic Flux to Inhibit Cognitive Impairment in Streptozotocin-induced Diabetic Rats by Up-regulation of Ornithine Decarboxylase/Spermidine Pathway
作者单位：Department of Neurologythe Second Affiliated HospitalUniversity of South China Department of PhysiologyMedical CollegeUniversity of South China Department of Anesthesiologythe First Affiliated HospitalUniversity of South China Department of NeurologyNanhua Affiliated HospitalUniversity of South China
会议名称：《中国生理学会张锡钧基金会第十四届全国青年优秀生理学学术论文交流及评奖会议、中国生理学会第十二届全国青年生理学工作者学术会议》
会议日期：2017年
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
关 键 词：autophagic flux diabetes-induced cognitive impairment hippocampal ornithine decarboxylase/spermidine pathway hydrogen Sulfide sodium hydrosulfide
摘 要：We have previously demonstrated the improving role of hydrogen sulfide（HS）,the third gasotransmitter,in the cognitive function of streptozotocin（STZ）-induced diabetic *** has been confirmed that impaired hippocampal autophagic flux has a key role in the pathogenesis of cognitive impairment and that ornithine decarboxylase（ODC）/spermidine（Spd） pathway plays an important role in the formation of memory by promoting autophagic ***,we investigated the roles of hippocampal ODC/Spd pathway and autophagic flux in HS-attenuated cognitive impairment in streptozotocin（STZ）-induced diabetic *** this study,we found that sodium hydrosulfide（NaHS,a donor of HS） up-regulated the expression of ODC and the level of Spd in the hippocampus of STZ-induced diabetic *** also found that NaHS markedly improved the autophagic flux in the hippocampus of STZ-exposed rats,as evidenced by the increases in the numbers of autophagosomes as wells as the expressions of LC3-Ⅱ,Beclin-1,and P62 in the hippocampus of cotreatment with NaHS and STZ ***,difluoromethylomithine（DFMO,an inhibitor of ODC） markedly prevented the up-regulated role of NaHS in the level of hippocampal Spd and reversed the protection of NaHS against the impairments in hippocampal autophagic flux as well as cognitive function in STZ-exposed *** findings indicated that improving hippocampal autophagic flux plays a key role in HS-attenuated cognitive impairment in STZ-induced diabetic rats,which is mediated by up-regulation of hippocampal ODC/Spd pathway.