The utilization of antiepileptic drugs on monotherapy and polytherapy for children at Shanghai in China
作者单位：Department of PharmacyChildren’s Hospital of Fudan University
会议名称：《第十三届江浙沪儿科学术会议暨2016年浙江省医学会儿科学学术年会》
会议日期：2016年
学科分类：1007[医学-药学(可授医学、理学学位)] 10[医学]
关 键 词：monotherapy polytherapy antiepileptic drugs children
摘 要：Objective:It was well known that the utilizations of antiepileptic drugs had been showed in many countries,such as Italy,Netherlands,Dutch,and so ***,those in China were rarely *** this article,the AEDs using pattern in clinic for children at Shanghai of China were ***,the application of monotherapy and polytherapy of AEDs was analyzed to assess whether drug mono-and polytherapy are rational or ***:In this research,8160 prescriptions of total 1,483,061 children aged 0-18 years in the Children’s hospital of Fudan university on the diagnosis of epilepsy were retrieved from July 2014 to October *** pattern of AEDs and the individual AED applied to monotherapy and polytherapy on using rate and dosage were ***,the utilization of valproic acid(VPA),levetiracetam(LEV) and topiramate(TPM) prescribed to different ages of children was ***:Children aged from 2 years to 11 years were the most frequency in the prescriptions with 74.07%.VPA solution,LEV tablet,Oxcarbazepine(OX) tablet and TPM were in the highest frequency used both in monotherapy and ***,proportion of older AED and newer AED on polytherapy arrived at 59.83%and 53.84%,which was higher than those of monotherapy with 18.67%and 39.63%.Furthermore,the dosage was increased from 9.50 ± 0.17 ml to 11.49 ± 0.34 ml in VPA group,from 4.79 ± 0.1 1 ml to 5.61 ± 0.19 ml in LEV group and from 59.45 ± 2.46 mg to 77.34 ± 3.06 mg in TPM with the number of medication added on polytherapy,which were significantly higher than ***:The usage of newer AED in children was all-too-frequency at Shanghai of China,while polytherapy was most commonly used in Chinese children,and certain different dose between monotherapy and polytherapy was found in VPA,LEV,and TPM.