Role of TXNDC5 in multiple myeloma
作者单位：State Key Laboratory of Medical Molecular BiologySchool of Basic MedicinePeking Union Medical CollegeInstitute of Basic Medical SciencesChinese Academy of Medical Sciences
会议名称：《第八届全国医学生物化学与分子生物学第五届全国临床应用生...》
会议日期：2013年
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
关 键 词：TXNDC5 multiple myeloma
摘 要：Objective:Multiple myeloma is a plasma cell malignancy which generally develops destructive osteolytic bone *** thiored oxindomain containing five(TXNDC5) is a protein-disulfide isomerase of thioredoxin *** study aimed at understanding the role of TXNDC5 in multiple ***:Western blot was used to detect the protein level of *** proliferation was evaluated by MTS *** was applied to analyze the amount of secreted Lambda light chain in multiple myeloma ***:The result showed that the protein level of TXNDC5 was much higher in multiple myeloma cell lines *** and U266 B1 than in RPMI18226 *** differential expression suggested that TXNDC5 may be involved in the phenotypes of multiple myeloma *** of TXNDC5 by specific siRNA reduced both cell proliferation and the secretion of Lambda light chain in MM.1 S ***:The above results indicate that TXNDC5 is probably involved in the development of multiple myeloma.