Role of MicroRNAs in Prostate Cancer Pathogenesis
会议名称：《中国中西医结合学会泌尿外科专业委员会第十四次全国学术会议暨2016年广东省中西医结合学会泌尿外科专业委员会学术年会》
会议日期：2016年
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
关 键 词：Androgen Apoptosis Cancer stem cells Epithelial to mesenchymal transition Metastasis
摘 要：Prostate cancer(PCa) remains the most commonly diagnosed malignant tumor in men,and is the second highest cause of cancer mortality after lung tumors in the United States. Accumulating research indicates that micro RNAs(mi RNAs) are increasingly being implicated in PCa. mi RNAs are conserved small noncoding RNAs that control gene expression posttranscriptionally. Recent profiling research suggests that mi RNAs are aberrantly expressed in PCa,and these have been implicated in the regulation of apoptosis,cell cycle,epithelial to mesenchymal transition,PCa stem cells,and androgen receptor pathway. All of these might provide the basis for new pproaches for PCa. Here,we review current findings regarding mi RNA research in PCa to provide a strong basis for future study aimed at promising contributions of miRNA in PCa.