Deficiency in the epigenetic factor CDYL disrupts neuronal migration and increases susceptibility to epilepsy
作者单位：Neuroscience Research Institute and Department of Neurobiology School of Basic Medical Sciences Key Laboratory for Neuroscience Ministry of Education/National Health and Family Planning Commission Peking University Department of Anatomy Histology and Embryology School of Basic Medical SciencesPeking University Health Science Center PKU-IDG/McGovern Institute for Brain Research Peking University
会议名称：《中国神经科学学会第十二届全国学术会议》
会议日期：2017年
学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学]
关 键 词：Epigenetic neuronal migration epilepsy
摘 要：Objective During brain development, the correct migration of newborn neurons is one of the determinants of circuit formation, and neuronal migration defects may lead to many psychiatric disorders. However, the molecular mechanisms of neuronal migration and disorders related to its defects are poorly understood. The present study is to explore how CDYL, an epigenetic factor regulates brain neurodevelopment. Methods The expression level of CDYL during embronic period was repressed by means of In utero Electroporation. The expression of neurodevelopment-related genes was measured by q PCR. Pentylentetrazol was injected intraperitoneally to induce acute seizures. Results（1） Knocking down CDYL caused neuronal migration defects and disrupted the mobility and multipolar-bipolar transition of the migrating neurons.（2） CDYL regulates neuronal migration by transcriptionally repressing Rho A.（3） CDYL deficiency increases the excitability of cortical pyramidal neurons and the susceptibility of mice to convulsantinduced seizures. Conclusion CDYL is a new regulator of neuronal migration and may play a role in the pathogenesis of seizure-related neurodevelopmental disorders.