The role of A3 in self-renewal maintenance of neural progenitors
作者单位：Institute of Neuroscience Shanghai Institutes for Biological Sciences Chinese Academy of Sciences
会议名称：《中国神经科学学会第十二届全国学术会议》
会议日期：2017年
学科分类：0710[理学-生物学] 07[理学] 071006[理学-神经生物学]
关 键 词：outer subventricular zone basal progenitors stem cell self-renew
摘 要：Objective Gyrencephaly is a unique structure found in limited species including human beings. Since the expansion of neocortex providing the structure for much more neurons to form complex network, it is of importance to investigate the mechanism of cortex folding conformation. According to previous studies, researchers have found that outer subventricular zone（OSVZ） is specially appears in species with complex neocortex. Further observations suggest that outer radial glial cells may be a major cause of neocortex. At the level of gene expression, A3 is highly expressed in OSVZ. In vivo overexpression A3 showed the potent increase of the number of proliferative progenitors. Besides, A3 knockdown causes neurogenesis defect both in vitro and in vivo. In several loss-of function experiments, A3 knockdown decrease progenitor’s pool with mitotic delay and spindle structure disrupted. Base on the potential function of A3 and related observation, we hypothesize that A3 plays a role in maintaining the basal progenitors self-renew and development potency in OSVZ.