Effects of maternal serum 25-hydroxyvitamin D levelson gestational diabetes and other pregnancy outcomes
作者单位：Nanjing Maternity and Child Health Care InstituteNanjing Maternity and Child Health Care Hospital Affiliated to Nanjing Medical University Department of Children Health CareNanjing Maternity and Child Health Care Hospital Affiliated to Nanjing Medical University State key Laboratory of Reproductive MedicineNanjing Maternity and Child Health Care Hospital Affiliated to Nanjing Medical University Department of ObstetricsNanjing Maternity and Child Health Care Hospital Affiliated to Nanjing Medical University Department of NutritionNanjing Maternity and Child Health Care Hospital Affiliated to Nanjing Medical University Institute of PediatricsNanjing Medical University
会议名称：《第十三届江浙沪儿科学术会议暨2016年浙江省医学会儿科学学术年会》
会议日期：2016年
学科分类：1002[医学-临床医学] 100211[医学-妇产科学] 10[医学]
关 键 词：25-hydroxyvitamin D gestational diabetes pregnancy outcomes
摘 要：Background:Studies that reported the association between maternal 25-hydroxyvitamin D[25(OH)D]levels and pregnancy outcomes have been ***:In this nested case-control study,we measured serum 25(OH)D in 4718 women who were attending second-and third-trimester screening in Nanjing,*** regression analysis was used to assess the association of 25(OH)D levels with gestational diabetes and other pregnancy ***-analysis and receiveroperator characteristic(ROC) curves were also ***:The median(IQR) serum concentrations of 25(OH)D for the total population was 43.7(35.5-57.9)nmol/L,and 63.1%of women had concentrations 50.0 nmol/*** 25(OH)D levels was significant lower in gestational diabetes cases than ***,after adjustment for confounders,women with low 25(OH)D levels was significandy associated with increased risks of gestational diabetes and some adverse pregnancy outcomes(anemia,macrosomia,abnormal amniotic fluid,and miscarriage or stillbirth).We also observed a threshold for 25(OH)D of50.0 nmol/L existed for gestational diabetes and a nice predictive accuracy of the 25(OH)D levels included panel,with area under the curve(AUC) at 0.625 for gestational ***:Low 25(OH)D levels( 50.0 nmol/L) in pregnancy was significantly associated with gestational diabetes risk,and it may serve as biomarkers for the surveillance of high-risk pregnant women.