GM-CSF-CTA2/(CTB-PSMA)5 increases the efficacy of a peptide vaccine against prostate cancer in mice model
作者单位：Guangdong University of Technology
会议名称：《第十二届全国免疫学学术大会》
会议日期：2017年
学科分类：1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100214[医学-肿瘤学] 10[医学]
关 键 词：cytokine peptide vaccine immunogenicity prostate cancer
摘 要：Therapeutic cancer vaccine are attractive due to the prospect of specificity and their lack of ***,their immunogenicity of antigen peptide has hampered the clinical *** *** adjuvant for huamn vaccine,containing AB5 molecular structure,is available to be equipped with a cytokine adjuvant and five antigen ***-CSF could not only stimulate stem cells proliferation but surprised results in a synergistic effect when combined with CTB-PSMA *** vaccine was evaluated in mice model through vitro and vivo *** result determined that both the immunogenicity and the protective effect of chimera protein GM-CSF-CTA2/(CTB-PSMA)5 were much better than that of single ***,GM-CSF-CTA2/(CTB-PSMA)5 is a candidate of prostate cancer vaccine.