The Role of Metabolism in 3,4-（Methylenedioxy）amphetamine-Mediated Serotonergic Neurotoxicity
作者单位：Dept.of Pharmacology ＆ Toxicology and the Southwest Environmental Health Sciences CenterCollege of PharmacyUniversity of Arizona
会议名称：《第二届中国药物毒理学年会（2012）》
会议日期：2012年
学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学]
基 金：Supported by awards from the NIH DA023525, T32ES016652,P30ES006694
摘 要：正3,4-（Methylenedioxy）methamphetamine（MDMA;Ecstasy） is a widely used and abused amphetamine analog, typically consumed by young adults at raves andtecho*** produces a selective serotonergic neurotoxicity when administered to rodents and nonhuman primates,and there is evidence that similar effects may occur in *** is manifest as longterm decreases in serotonin（5-HT） concentrations in brain regions enriched in 5-HT nerve terminals,and in axonal *** of MDMA directly into the