Attenuation of Capacitative Calcium Entry by γ-secretase Cleavage of Stromal Interaction Molecule 1 as a Pathogenic Mechanism for Familial Alzheimer's Disease
作者单位：Department of PhysiologyLKS Faculty of MedicineUniversity of Hong Kong University of Hong Kong Shenzhen Institute of Research and Innovation
会议名称：《第四届全国痴呆与认知障碍学术研讨会及高级讲授班》
会议日期：2015年
学科分类：1002[医学-临床医学] 100203[医学-老年医学] 10[医学]
摘 要：Abnormalγ-secretase cleavage of amyloid precursor protein(APP)to amyloid beta(Aβ)has been shown to play an important role in Alzheimer’s disease(AD)pathogenesis.γ-secretase is a multimeric intramembranous protease that cleaves various type-I transmembrane *** presenilin-1(PS1)being the catalytic core ofγ-secretase,many FAD-linked PS1 mutations enhance proteolytic activity that