Loss of heterozygosity at chromosomes 6p and 15q;HLA-I,HLA-G and IL-10 expression in cervical cancer biopsies.

作     者：Josefa Antonia Rodriguez Garcia Martha Lucia Serrano Lopez Liliana Galeano Petro Constanza Gomez Diana Maria Palacios Ortiz Maria Mercedes Bravo Hernandez Alba Lucia Combita Rojas 

作者单位：InstitutoNacional de Cancerologia InstitutoNacional de Cancerologia InstitutoNacional de Cancerologia InstitutoNacional de Cancerologia FundacionSanta Fe InstitutoNacional de Cancerologia InstitutoNacional de Cancerologia 

会议名称：《24th International Papillomavirus Conference and Clinical Workshop》

会议日期：1000年

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

摘      要：正Immune evasion in cancer can result from structural and functional alterations in HLA-1 molecules and from the local release of immunosuppressive *** of heterozygosity（LOH）in HLA（6p21.3）and B2-m（15q21）regions is associated with HLA-1 down regulation in tumours HLA-G,a no classical class I molecule,and IL-10 are implicated in immune evasion in cancer