Asymmetric Sulfa-Michael Addition to α-Substituted Vinyl Ketones Catalyzed by Chiral Primary Amine
作者单位：Beijing National Laboratory for Molecular Sciences（BNLMS）CAS Key Laboratory for Molecular Recognition and FunctionInstitute of Chemistrythe Chinese Academy of Sciences
会议名称：《手性中国2014学术研讨会》
会议日期：2014年
学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学]
摘 要：正Asymmetric sulfa-Michael addition（SMA）of thiol nucleophiles to electron-deficient alkenes is one of the most versatile and reliable methods for the synthesis of chiral sulfur-containing compounds,that are of significant potential in pharmaceuticals.1 Despite tremendous progress on catalytic asymmetric sulfa-Michael addition reactions over the decades,2 enantioselective sulfa addition to a-substituted vinyl