Cottontail Rabbit PapiUomavirus Genomes Containing E7 Codons Optimized for Expression in Mammals are Viable and Respond to Immunization with the Wild Type E7 Gene
作者单位：PennsylvaniaState University College Of Medicine PennsylvaniaState University College Of Medicine PennsylvaniaState University College Of Medicine
会议名称：《24th International Papillomavirus Conference and Clinical Workshop》
会议日期：2007年
学科分类：1001[医学-基础医学(可授医学、理学学位)] 10[医学]
摘 要：正Abundant observations have shown that synonymous codon ＆ldquo;optimization＆rdquo;of papillomavirus genes can lead to increased protein expression in vitro We have undertaken studies to alter codons in the context of the viral genome in order to took at responses in vivo For this study,we have focused on the oncoprotein E7 of the cottontail rabbit papillomavirus （CRPV）and have made a series of changes,each building upon the previous alterations Genomes with 8（E7/8）,14（E7/14）,18