Prenatal PAHs Exposure and neonatal Neurobehavioral Development
作者单位：Department of Occupational HealthSchool of Public HealthShanxi Medical University
会议名称：《2016中国毒理学会神经毒理专业委员会学术年会》
会议日期：2016年
学科分类：100405[医学-卫生毒理学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 10[医学]
基 金：supported by the National Natural Science Foundation of China(81072279 and 30800899) the Shanxi Province Natural Science Foundation of China(2015011128 and 2010021034-3) Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi(20081014)
关 键 词：Prenatal Polycyclic aromatic hydrocarbons(PAHs) Exposure neonatal Neurobehavioral Development birth cohort animal model
摘 要：Polycyclic aromatic hydrocarbons（PAHs） are ubiquitous air pollutants generated by combustion of organic material,including fossil *** has been an open question whether prenatal exposure to air pollution in general and PAHs in particular significantly increases the risk of neonatal neurobehavioral ***,we have examined this hypothesis in a birth cohort in Taiyuan City and a benzo[a]pyrene exposure animal model.297 pregnant women enrolled in Taigang Hospital and the eighth Taiyuan people’s hospital in Taiyuan city from November 2009 to May 2010.A cohort of the mothers and their neonates participated in the study and information on each subject was obtained by *** metabolites were detected in the urine of mothers during pregnancy to evaluate the exposure level to *** neurobehavioral developmental levels were assessed according to the standards of the Neonatal Behavioral Neurological Assessment（NBNA）.A 1 natural-log（ln）-unit increase in prenatal PAH exposure was associated with a 0.44 score decrease in total Score and with a 0.143 score decrease in behavior score as well as 0.153 passive tone score and 0.158 primary reflexes score of *** total scores,behavior scores,passive tone scores,and primary reflexes scores between male and female newborns were not significantly *** animal study,Pregnant rats were exposed to benzo[a]pyrene at three dosages（25 mg/kg B[a]P,50 mg/kg B[a]P,100 mg/kg B[a]P）.Neonatal development was evaluated at ages of 4,7,14 and 28 *** development time of ear opening,body weight),behavior development（surface righting reflex,olfactory discrimination） and learning and memory in offspring were impaired in a B[a]P dose dependent *** results in human population and animal model showed that Prenatal PAHs Exposure was the predominant risk factor for neonatal neurobehavioral development.