EXPERIMENTAL EVALUATION OF BLOCKING EFFECT ON EMBOLI IN THE AORTA ASCENDENS BY USING PHASED ARRAY ULTRASOUND
作者单位：School of Biomedical Engineering Shanghai Jiao Tong University Department of Cardiothoracic Surgery Xinhua Hospital School of Medicine Shanghai Jiao Tong University
会议名称：《2016年全国压电和声波理论及器件应用研讨会》
会议日期：2016年
学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 100207[医学-影像医学与核医学] 1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 08[工学] 1010[医学-医学技术（可授医学、理学学位）] 10[医学]
基 金：supported by the Shanghai Jiao Tong University Medical Engineering Research Fund (Grant No. YG2013MS19) the Shanghai Key Technology R&D Program (Grant No. 15441901200)
关 键 词：Phased array ultrasound Ultrasonic radiation force Emboli Experimental evaluation
摘 要：Background, Motivation and Objective Neurologic complications, such as transient ischemic attack, stroke and cognitive decline, are common complications after cardiac surgery. They can not only disable patient or take away patient’s life but also cause heavy financial and mental burden upon the patients and their family. The reason of neurologic complications is related to gaseous and solid emboli of head blood vessel which are generated in extracorporeal circulation and surgical operation. Therefore, it is very meaningful to block gaseous and solid emboli from flowing into head from the right common carotid artery. Ultrasound field can generate ultrasonic radiation force acting on embolic and may block emboli from flowing into some blood vessels. This study is aimed to evaluate the blocking effect of the phased array ultrasound on emboli. Statement of Contribution/Methods We did experiments on eight pigs(40kg). After opening thorax, we positioned ultrasound transducer between aorta ascendens and truncus brachiocephalicus. And emboli were detected by PHILIPS CX50 on the right common carotid artery. Air embolic used every time were created by mixing 1 ml air with 9 ml normal saline and polystyrene particles(Duke Corp) dissolved in normal saline as the solid emboli. Both kinds of emboli were injected in the left auricle 8 times on each pig. 4 times with ultrasound transducer off and 4 times with ultrasound transducer on. The emboli which flowed into the right common carotid artery were detected and analyzed. At the end of the experiment, the sonicated tissue was cut for histopathology test. Results The histopathology test showed that the sonicated tissue was not injured. The use of phased array ultrasound significantly reduced the number of emboli which flowed into the right common carotid artery. The gaseous emboli reduced by 69% and the solid emboli reduced by 61%. Discussion and Conclusions The research revealed that use of phased array ultrasound is a safe way to