Angiogenin prevents progranulin A9D mutation induced neuronallike cell apoptosis through cleaving t RNAs into tiRNAs
作者单位：Institute of Environmental Health Zhejiang University School of Medicine Program in Molecular Cell Biology Zhejiang University School of Medicine Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases Zhejiang University
会议名称：《中国生物化学与分子生物学会2016年全国学术会议》
会议日期：2016年
学科分类：1002[医学-临床医学] 100203[医学-老年医学] 10[医学]
关 键 词：Angiogenin Progranulin Neurodegenerative diseases tiRNA
摘 要：Gene defects have been recognized as prominent factors in the etiology and pathogenesis of *** 60neurodegeneration-related mutations in progranulin(PGRN),the mutation in PGRN gene exon 1 introduces a charged amino acid in the hydrophobic core of its signal peptide at residue 9(thus named as PGRN A9D)and results in cytoplasmic mis-