The role of Hippo signaling in maintaining organelle homeostasis
作者单位：State Key Laboratory of Cellular Stress Biology Innovation Center for Cell Signaling NetworkSchool of Life Sciences Xiamen University
会议名称：《中国生物化学与分子生物学会2016年全国学术会议》
会议日期：2016年
学科分类：0710[理学-生物学] 07[理学] 071009[理学-细胞生物学] 09[农学] 0901[农学-作物学] 090102[农学-作物遗传育种]
摘 要：The Hippo signaling pathway is a critical regulator of stem cell self-renewal,tissue regeneration and organ size The Ste20-like kinases Mst 1 and 2(Mst1/2),the mammalian Hippo orthologs,are key components of the Hippo signalling *** found that loss of Mst1/2,or their regulator WW45,leads to a remarkably enlarged endoplasmic reticulum(ER)size-associated unfolded protein response(UPR).Intriguingly,