Encephalomyocarditis Virus 3C Protease relieves TANK Inhibitory Effect on TRAF6-mediated NF-kappaB Signaling through Cleavage of TANK
作者单位：State Key Laboratory of Veterinary BiotechnologyHarbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences College of Life SciencesYangtze University Faculty of Life Science and TechnologyKunming University of Science and Technology Department of MicrobiologyHarbin Medical University
会议名称：《中国畜牧兽医学会生物技术学分会暨中国免疫学会兽医免疫分会第十二次学术研讨会》
会议日期：2016年
学科分类：090601[农学-基础兽医学] 09[农学] 0906[农学-兽医学]
关 键 词：encephalomyocarditis virus 3C protease cleavage TANK TRAF6 NF-κB
摘 要：TKAF family member-associated NF-kB activator(TANK) is a negative regulator of canonical NF-kB signaling in the Toll-like receptor(TLR)-and B-cell receptor(BLR)-mediated signaling ***,functions of TANK in viral infection-mediated NF-kB activation remain *** we reported that TANK was cleaved by encephalomyocarditis virus(EMCV) 3C at the 197 and 291 glutamine residues,which depends on its cysteine prolease *** addition,EMCV 3C impaired the ability of TANK to inhibit TRAF6-mediated NF-kB ***,we found that several viral proteases encoded by foot and mouth diseases virus(FMDV),porcine reproductive and respiratory syndrome virus(PRRSV) and equine arteritis virus(EAV) also cleaved *** results suggest that TANK is a novel target of some viral proteases,indicating that some positive RNA viruses have evolved to utilize their major proteases to regulate NF-kB activation.