Site-specific Proteasome Phosphorylation Controls Cell Proliferation and Tumorigenesis
作者单位：Department of Pharmacology University of California-San Diego Life Sciences Institute Zhejiang University Departments of Physiology and Biophysics and of Developmental and Cell Biology University of California Division of Biological Sciences University of California-San Diego Department of Neurobiology Zhejiang University School of Medicine Departments of Cellular and Molecular Medicine and of Chemistry and Biochemistry University of California-San Diego
会议名称：《中国生物化学与分子生物学会2016年全国学术会议》
会议日期：2016年
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
关 键 词：Proteasome Phosphorylation DYRK2 Cell Cycle Tumorigenesis CRISPR/Cas9
摘 要：Despite the fundamental importance of proteasomal degradation in cells,little is known about whether and how the 26S proteasome itself is regulated in coordination with various physiological processes.Here we show that the proteasome is dynamically phosphorylated during cell cycle at Thr25 of the 19S subunit Rpt3.CRISPR/Cas9-mediated genome editing,