IL-27 local and systemic delivery induces anti-tumor immunity via different mechanisms: implications for the design of IL-27-based cancer vaccine
作者单位：Pediatric Translational Medicine Institute Shanghai Children’s Medical Center Shanghai Jiaotong University School of Medicine
会议名称：《第十一届全国免疫学学术大会》
会议日期：2016年
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
关 键 词：IL-27 antitumor activity cancer vaccine adjuvant
摘 要：IL-27 is an anti-inflammatory cytokine with potent antitumor activity.Studies using preclinical mouse models have revealed that IL-27 exert its antitumor activity via various mechanisms including induction of anti-tumor T cell responses.To determine if IL-27 has the potential to be used as a cancer vaccine or vaccine adjuvant,we first generated IL-27-secreting B16.F10 cells(B16-IL-27)and compared B16-IL-27 with GM-CSF-secreting B16.F10 cells