GSK3β activity that can be regulated by AICAR via stimulated AKT in preadipocytes is involved in the regulation of adipogenesis, glucose metabolism and insulin action in adipocytes
作者单位：Metabolomics Core Faculty of Health Sciences University of Macau Faculty of Health Sciences University of Macau
会议名称：《中国生物化学与分子生物学会2016年全国学术会议》
会议日期：2016年
基 金：supported by Grants FDCT 025/2014/A1 and FDCT 088/2014/A2 from the Science and Technology Development Fund (FDCT) of Macao SAR (to L. J. D.) by Multiyear Research Grants MYRG201500037FHS and MYRG201500167FHS from the University of Macau (to L. J. D.)
关 键 词：AICAR GSK3 AKT Adipogenesis Glucose uptake
摘 要：Adipogenesis is a tightly regulated cellular differentiation process and the understanding of mechanism and manipulation of adipogenesis might contribute to a reduction in the burden of obesity and diabetes.Multiple transcription factors and signaling pathways are involved in the regulation of adipogenesis.Here we report that in preadipocytes,AMP-activated protein kinase activator,5-aminoimidazole-4-carboxamide ribonucleoside(AICAR)can activate AMPK to increase GSK3β