C-C motif chemokine ligand 2(CCL2) mediates acute lung injury induced by lethal influenza H7N9 virus
作者单位：State Key Laboratory of Pathogens and BiosecurityBeijing Institute of Microbiology and Epidemiology Beijing 302 Hospital
会议名称：《第十一届全国免疫学学术大会》
会议日期：2016年
学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 100401[医学-流行病与卫生统计学] 10[医学]
摘 要：An avian-origin influenza A(H7N9) virus has raised concern in China in the spring of 2013. Most H7N9 infections cases resulted in acute respiratory distress syndrome(ARDS), which is a severe form of acute lung injury(ALI) that further contributes to morbidity and mortality. In this study,we report a close association of CCL2 expression and acute lung injury induced by lethal H7N9 virus strain(A/Hebei/01/2013) in a mouse model. Elevated CCL2 levels were detected inconfirmed H7N9 patients and the bronchoalveolarlavage fluid(BALF) of H7N9 infected mice. Moreover, the overexpressions of CCL2 were observed in lung tissue of infected mice post infection. More importantly, CCL2 deficiency ameliorated acute lung injury induced by H7N9 virus in mice as determined by weight loss, survival rates, lung wet dry ratio and *** together, our findings demonstrated that CCL2 were essential for H7N9 virus infection andinterfering CCL2 might be promising as a potential therapeutic target for future influenza pandemic.