Blockade of IDO-kynurenine-Ah R metabolic circuitry abrogates IFN-γ-induced immunologic dormancy of tumor-repopulating cells
作者单位：State Key Laboratory of Medical Molecular Biology & Department of Immunology Institute of Basic Medical Sciences Chinese Academy of Medical Sciences Department of Biochemistry & Molecular Biology Tongji Medical College Huazhong University of Science & Technology
会议名称：《第十一届全国免疫学学术大会》
会议日期：2016年
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
关 键 词：IFN-γ tumorigenic cell immunologic dormancy molecular mechanism immunotherapy
摘 要：Purpose:Interactions with the immune system might lead tumorigenic cells into immunologic ***,the underlying molecular mechanism is poorly *** is a very meaningful field that need to dig ***:We used a previously described 3D-culture system and added with IFN-γto induce tumorigenic cells to enter *** use other molecular methods like PCR,western-blot,immunoprecipitation etc,to test the inner mechanism,meanwhile,mouse models also had been used to test the hyposis in vivo.