Dual targeting and enhanced cytotoxicity to HER2-overexpressing tumors by immunoapoptotin-armored mesenchymal stem cells
作者单位：The State Key Laboratory of Cancer Biology Department of Biochemistry and Molecular BiologyFourth Military Medical University Department of Anesthesiology Xijing Hospital Fourth Military Medical University School of Pharmacy Shanxi Medical University The State Key Laboratory of Cancer Biology Department of Immunology Fourth Military Medical University
会议名称：《中国生物化学与分子生物学会2016年全国学术会议》
会议日期：2016年
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
关 键 词：Mesenchymal stem cells Immunoapoptotin HER2-positive tumors Gene transduction Dual tumor targeting
摘 要：Mesenchymal stem cells(MSCs)are promising vehicles for the delivery of anticancer agents in cancer ***,the tumor targeting of loaded therapeutics is ***,we explored a dual-targeting strategy to incorporate tumortropic MSC delivery with HER2-specific killing by the immunoapoptotin e23s Fv-Fdt-t Bid generated in our previous studies.