Emerging role of long noncoding RNAs in autoimmune diseases
作者单位：Department of Epidemiology and BiostatisticsSchool of Public HealthAnhui Medical University Anhui Provincial Laboratory of Population Health and Major Disease Screening and DiagnosisAnhui Medical University Department of NephrologyThe Second Affiliated Hospital of Anhui Medical University Department of Rheumatology and ImmunologyAnhui Provincial HospitalAffiliated to Anhui Medical University
会议名称：《2015年度安徽省流行病与卫生统计学学术论坛》
会议日期：2016年
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：supported by grants from the National Natural Science Foundation of China (81102192,81172764) the Specialized Research Fund for the Doctoral Program of Higher Education of China (20113420120008)
关 键 词：lncRNA Noncoding RNA Immune function Autoimmunity Autoimmune disease
摘 要：Long noncoding RNA(lncRNA),with size larger than 200 nucleotides,is a new class of noncoding *** evidence has revealed that lnc RNAs play a key role in the regulation of immunological functions and ***,we review the recent findings of lnc RNA regulation in immune functions and in the development of autoimmunity and autoimmune *** addition,we focus on the involvement of lnc RNA regulation in innate and adaptive immune responses,immune cell development,and differential expression of lnc RNAs in autoimmune diseases,including systemic lupus erythematosus(SLE),rheumatoid arthritis(RA),type 1 diabetes mellitus(T1DM),multiple sclerosis(MS),autoimmune thyroid disease(AITD),psoriasis,polymyositis/dermatomyositis(PM/DM) and Crohn’s disease(CD).