Pharmacokinetic Study of Ginsenoside Re in Healthy Adult Volunteers
会议名称：《2008 International Conference on Ginseng》
会议日期：2008年
学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学]
关 键 词：ginsenoside Re high performance liquid chromatography-tandem mass spectrometry pharmacokinetics
摘 要：Aim To investigate the pharmacokinetics of ginsenoside Re(G-Re)in Chinese healthy *** An open-label,randomized and crossover clinical trials recruited 16 healthy volunteers were carried out for single-dose(100 and 200mg)and multiple-doses(100mg×2/d×7d) administration *** concentrations of G-Re and its metabolites in human plasma and urine were determined using HPLC-MS/MS *** Pharmacokinetic parameters were determined from plasma G-Re *** single-dose administration,there was no statistical difference of Tbetween 100 and 200mg doses,and the accumulative excretion rate of G-Re from urine after 24h administration were(0.0036±0.0021)% and(0.0017±0.0011)% for 100 and 200mg doses,*** multiple-doses administration,the values of Cand AUCof d7 were the double to those of d1,and no statistically significant difference was seen in Tand ln Cbut was seen in *** accumulative excretion rate of G-Re from urine after d7 administration were(0.0046±0.0025)%.Conclusion The present studies indicated that G-Re after orally in single-dose or multiple-doses administration is minimally absorbed and excretion from urine in *** are not significant differences of the pharmacokinetic parameters between single-dose and multiple-doses study except for AUC.