A Simple Primary Amine Derived from Cyclohexanediamine Catalyst for Asymmetric Direct Aldol Reaction

作     者：Chen,Guodong Li,Chao Fu,Xiangkai~* (College of Chemistry and Chemical Engineering,Research Institute of Applied Chemistry Southwest University The Key Laboratory of Applied Chemistry of Chongqing Municipality,Chongqing 400715) 

会议名称：《有机合成创新—产业化的新动力——中国化学会全国第三届有机合成化学与过程学术讨论会》

会议日期：2010年

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

关 键 词：primary amine cyclohexanediamine aldol reaction asymmetric catalysis 

摘      要：The aldol reaction,which is used in nature for building of carbohydrate molecules through the use of aldolase enzymes,is recognized as one of the most efficient methods for the formation of carbon-carbon bonds in organic Synthesis Since the first reports on the asymmetric direct aldol reactions catalyzed by L-proline,many organocatalysts have been synthesized with the aim of increasing their reactivity and *** group recently reported the 4-phenoxy substituted and 4-tertbutyldimethylsiloxy-substituted prolinamides catalyze the