Effects of Intermittent Hypobaric Conditions on Chronically Exercised Rat Hearts
作者单位：University of Istanbul Cerrahpasa Faculty of Medicine Dept. of Pharmacology and Clinical Pharmacology Istanbul TURKEY University of Istanbul Cerrahpasa Faculty of Medicine Dept. of Physiology Istanbul TURKEY University of Istanbul Cerrahpasa Faculty of Medicine Dept. of Physiology Istanbul TURKEY University of Istanbul Cerrahpasa Faculty of Medicine Dept. of Physiology Istanbul TURKEY University of Istanbul Cerrahpasa Faculty of Medicine Dept. of Pharmacology and Clinical Pharmacology Istanbul TURKEY
会议名称：《第十五届国际药理学大会》
会议日期：2006年
学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学]
摘 要：正 Objective: A new approach for enhancing athletic performance is to expose intermittent hypoxia while exercise in normobaric conditions;we aimed to measure in vitro cardiac functions of rats in a setting which simulate this approach. Methods: The Wistar rats in group 1 stayed in a hypobaric cabinet 2 hours a day and 5 days a week for 9 weeks. Hypoxia simulated the PO2 pressure in 3000 meters of altitude. They swam 30 minutes/day for 4 days for 9 weeks. Group 2 stayed and exercised in normobaric conditions. Groups 3 and 4 simulated groups 1 and 2 re speetiely but these groups did not exercise. Then hearths were perfused in Lan gendorff apparatus where their basal and 7.5, 12.5 and 75 mg/L dobutamine treated cardiac performance were measured. Results: Diastolic function deteriorated in group 1 （-dp/dtmax982±443 vs. 1511±224 that of group 2, p = 0.040） . Basal heart rate of group 2 was lower than group 4 （p = 0.018） and that group had higher peak systolic pressure after dobutamine induction （at 7.5 mg/L concentration was 119% of baseline. p = 0.019）. Conclusions: Swimming in nor-mobaric conditions enhanced cardiac functions. However, intermittent hypobaric conditions deteriorated cardiac performance.