Targeted Therapies:The Importance of Signaling Molecules
作者单位：Ph.D. Professor University of California-San Diego DirectorLudwig Institute for Cancer Research-San Diego BranchLa JollaCA 92093-0660
会议名称：《第四届中国肿瘤学术大会暨第五届海峡两岸肿瘤学术会议》
会议日期：2006年
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
摘 要：正Advances in understanding the genetic basis of cancer have led to the identification of molecules that are specifically expressed in tumors. Such molecules represent targets for therapy whose targeting might be expected to have increased selectivity for tumor cells compared to normal tissue with resultant enhancements in effect and reductions in the non - specific toxicities that lead to chemotherapeutic side effects. Two such molecules are 1) a mutated form of the epidermal growth factor receptor （EGFR）;and, 2) the dual specificity phosphatase, PTEN. Both have been found in sizable proportions of tumors of the brain, lung, prostate and breast.