Inhibition of HIV Integrase by a Novel Dinucleotide

作     者：Hu Liming Li Xiaopeng Zhang Yuanchao Institute of Medicinal Chemistry, College of Life Science, Beijing University of Techonology, Beijing, 100022 

会议名称：《第七届全国磷化学化工暨第四届海峡化学生物学、生物技术与医药发展讨论会》

会议日期：2006年

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学] 

关 键 词：HIV Inhibition of HIV Integrase by a Novel Dinucleotide 

摘      要：Integrase is an enzyme found in human immunodeficiency virus, which is required for the viral life cycle, yet has no human cellular homologue. For this reason, HIV integrase (IN) has become an important target for the development of new AIDS therapeutics. In the quest for a small nucleotide system with nuclease stability of the internucleotide phosphate bond and critical structural features for recognition and inhibition of HIV-1 integrase, we have studied a