A recombinant chimeric protein containing B chains of ricin and abrin is an effective vaccine candidate
作者单位：State Key Laboratory of Pathogen and BiosecurityInstitute of Microbiology and EpidemiologyAcademy of Military Medical Sciences Tianjin Key Lab for Biomarkers Occupational and Environmental HazardMedical College of Chinese People’s Armed Police ForceChina Institute of Military VeterinaryAcademy of Military Medical Sciences Jilin Medical College
会议名称：《第十一届中国生物毒素研究及医药应用年会》
会议日期：2013年
学科分类：1001[医学-基础医学(可授医学、理学学位)] 100102[医学-免疫学] 10[医学]
摘 要：正Ricin and abrin,deadly plant toxins,with the greatest potential use as biological weapons and possible bioterrorist agents,have caused growing awareness on their vaccines and related diagnosis in recent *** are similar structures with two chains linked by a disulfide bond for ricin toxin（RT）and abrin toxin（AT）.A chain confers cellular toxicity while B chain is essential for cell *** of their easy availability,stability,and extraordinary toxicity,the use of them as bioterrorist weapons is of considerable concern. Dual subunit vaccine consisting of ricin toxin B chain（RTB）and abrin toxin B chain