Structural analysis of the Hepatitis C virus Ion channel p7 using electron microscopy
作者单位：Department of BiochemistryUniversity of OxfordUnited Kingdom Department of Life SciencesThe Ben-Gurion UniversityIsrael
会议名称：《21st IUBMB and 12th FAOBMB International Congress of Biochemistry and Molecular Biology》
会议日期：2009年
学科分类：1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 1001[医学-基础医学(可授医学、理学学位)] 100103[医学-病原生物学] 10[医学]
摘 要：正The Hepatitis C virus（HCV） p7 protein forms ion channels which are crucial for the assembly and secretion of infectious virus,making it a therapeutic target. The small（63 amino acid,7 kDa） and highly hydrophobic p7 protein has two transmembrane spanning helices connected by a short,hydrophilic loop facing the cytoplasm and with N- and C-termini facing the ER lumen.