miR-146a inhibits dengue virus induced autophagy by targeting TRAF6
作者单位：Department of ImmunologyInstitute of Human VirologyZhongshan School of MedicineSun Yat-sen University
会议名称：《第九届全国免疫学学术大会》
会议日期：2014年
学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学]
关 键 词：miR-146a autophagy DENV TRAF6
摘 要：Autophagy is a self-degrading process that is triggered by diverse stimuli including starvation,accumulation of misfolded proteins and infection *** role of autophagy in diseases,such as cancer and infections,has been ***,the signaling pathways regulating autophagy still remain ***,other groups reported that several microRNAs(miRNAs),such as miR-376b and miR-181a,are novel and potent modulators of the autophagic ***,we found that miR-146a is a new autophagy-regulating *** showed that overexpression of miR-146a abrogated DENV2-,rapamycin-and LPS-induced ***,LNA-mediated silencing of endogenous miRNA activity promoted ***,we demonstrated that silence of TRAF6,one of miR-146a targets,decreased DENV2-induced IFN-βexpression,and then abrogated *** co-overexpression of TRAF6 reversed the inhibition role of miR-146a on ***,miR-146a is a novel and important regulator of autophagy and TRAF6 is the direct target in this ***,our data showed that in A549 cells,autophagy promoted DENV2-induced TNF-αand IL-6 *** findings consummated the role of miR-146a in DENV infection,which might be vital in the pathogenesis of DENV diseases.