Induction of Species-Specific Tolerance to Human Islet Xenografts by anti-CD45RB
作者单位：Department of SurgerySichuan Provincial People's Hospital & Sichuan Academy of Medical Sciences Department of SurgeryMassachusetts General HospitalHarvard Medical School Department of Pediatrics and PathologyMicrobiologyand ImmunologyIan Burr Division of Endocrinology and DiabetesVanderbilt University
会议名称：《2013中国器官移植大会》
会议日期：2013年
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
摘 要：Transplantation for type 1 diabetes is severely limited by the lack of donor islets and by the rapid destruction of transplanted islets by innate and adaptive *** transplantation requires desirable engraftment,avoidance of immediate immune barriers,and long term escape from lymphocyte mediated *** clinical applicability of transplantation could be further enhanced by protocols that permit the use of xenogeneic islets as this advance would markedly increase the availability of donor islets to meet the significant *** addition,xenogeneic tolerance induction would substantially improve the study of human islet biology in animal model *** have utilized treatment with the monoclonal antibody against CD45RB to induce permanent acceptance of human islets in murine ***,depletion of B cells permitted universal tolerance induction andthis tolerance was species—specific.