Progress towards vaccines against helminth infections of livestock
作者单位：Moredun Research InstitutePentlands Science ParkBush LoanPenicuikScotland EH26 0PZ
会议名称：《中国畜牧兽医学会家畜寄生虫学分会第六次代表大会暨第十一次学术研讨会》
会议日期：2011年
学科分类：090603[农学-临床兽医学] 09[农学] 0906[农学-兽医学]
摘 要：Parasitic helminths express and secrete a variety of proteases which they use for many purposes including the penetration of host tissues,digestion of host protein for nutrients,evasion of host immune responses and for internal processes such as tissue catabolism and *** these broad reasons they have been examined as possible parasite control *** feeding nematodes such as Haemonchus contortus that infect sheep and goats and the hookworms,Ancylostoma *** Necator americanus, affecting man and trematodes such as Schistosoma and Fasciola spp.,use an array of endo and exopeptidases to digest the blood *** digestion occurs by an ordered and partly conserved proteolytic *** proteases are accessible to host immune responses which can block enzyme function and lead to parasite expulsion and/or *** they are receiving attention as components of *** genome revolution has provided the opportunity to identify many other targets and this process will be enhanced by the application of reverse genetics approaches such as RNA interference to enhance target validation.